Update with info from imdb. Erwin Stoff: "Manager of Keanu Reeves (since Reeves was 16)", one of the producers of The Day the Earth Stood Still remake with Keanu, and producer of 12 Keanu Reeves movies. I think Keanu is pretty much cast for this. They can make it a very stylish movie with almost anyone "hot" right now, mess with the characters, add a r&b, hip hop, and maybe some jazz soundtrack and people will love it. This will probably be for people who never saw the show or movie.
I predict Abigail Breslin as edward for marketing reasons. Charlize Theron, Angelina Jolie or Halle Berry as Faye. Brian Cox or Harrison Ford as Jet. A cg creation as ein. Keanu as Spike. Music by Branford Marsalis, Wynton Marsalis, Timbaland, Pharell, Herbie Hancock or maybe Gabriela Robin.